Chapter 3 Analytical Sociology amidst a Computational Social Science Revolution

"The Handbook of Computational Social Science is a comprehensive reference source for scholars across multiple disciplines. It outlines key debates in the field, showcasing novel statistical modeling and machine learning methods, and draws from specific case studies to demonstrate the opportunities and challenges in CSS approaches. The Handbook is divided into two volumes written by outstanding, internationally renowned scholars in the field. This first volume focuses on the scope of computational social science, ethics, and case studies. It covers a range of key issues, including open science, formal modeling, and the social and behavioral sciences. This volume explores major debates, introduces digital trace data, reviews the changing survey landscape, and presents novel examples of computational social science research on sensing social interaction, social robots, bots, sentiment, manipulation, and extremism in social media. The volume not only makes major contributions to the consolidation of this growing research field, but also encourages growth into new directions. With its broad coverage of perspectives (theoretical, methodological, computational), international scope, and interdisciplinary approach, this important resource is integral reading for advanced undergraduates, postgraduates and researchers engaging with computational methods across the social sciences, as well as those within the scientific and engineering sectors.

Applying the brakes: Does Prostaglandin Dehydrogenase promote mitotic quiescence in differentiated human urothelium?

The urothelium functions to provide and maintain a tight barrier in the urinary tract whilst retaining the ability to shift phenotype from being mitotically quiescent to rapidly regenerative in the event of injury or infection. Previous observations in the human urothelium have identified bioactive eicosanoids are released upon urothelial damage and can be synthesised within the urothelium itself. However limited studies have been performed to understand the roles, if any, of eicosanoid prostaglandin E2 in mediating normal urothelial tissue homeostasis. The aim of this study was to investigate the expression of components of the PGE2 metabolic pathway in human urothelial cells and assess the function in regulating mitotic quiescence and urothelial wound repair. Prostaglandin dehydrogenase (PGDH), whose function is to inactivate PGE2, was identified as having a differentiation-associated expression and localisation in normal human urothelial (NHU) cells in vitro and in situ. Pharmacological inhibition of PGDH activity disrupted mitotic quiescence by releasing urothelial cells into the cell cycle which suggested PGDH may function to retain cells in the G0 quiescent phase. PGDH inhibition also reduced barrier reformation during urothelial wound repair, and this was a cAMP-dependent process illustrating the importance of exogenous cholera toxin (CT) in NHU cell culture. Taken together, this study presents evidence that PGDH functions in differentiated human urothelium to degrade PGE2 whose accumulation compromises mitotic quiescence, a characteristic feature of human urothelium in situ

Positioning family planning quality within health financing for UHC: Connecting the discourse

Financing is a major challenge and concern for the future of the delivery of voluntary family planning (FP) services to clients, particularly in low- and middle-income countries with high unmet need and limited method choice. As countries commit to universal health coverage (UHC), it is crucial that UHC schemes include FP and other reproductive health (RH) services. Strategic purchasing of quality FP services from public and private—including for profit and not-for-profit—health-care providers could accelerate progress toward UHC. It is increasingly recognized that the FP2020 goals will not be met without adequate attention to quality, and that a sustained focus on quality of care requires financing at the policy and program levels. While the importance of sustainable financing may be recognized, the “how” of financing for quality FP within the context of UHC is not well understood. This brief targets the “bridge” constituency that is coalescing between the health financing and FP communities of practice around a shared interest in making access to health services universal

On The Specialization of Neural Modules

A number of machine learning models have been proposed with the goal of achieving systematic generalization: the ability to reason about new situations by combining aspects of previous experiences. These models leverage compositional architectures which aim to learn specialized modules dedicated to structures in a task that can be composed to solve novel problems with similar structures. While the compositionality of these architectures is guaranteed by design, the modules specializing is not. Here we theoretically study the ability of network modules to specialize to useful structures in a dataset and achieve systematic generalization. To this end we introduce a minimal space of datasets motivated by practical systematic generalization benchmarks. From this space of datasets we present a mathematical definition of systematicity and study the learning dynamics of linear neural modules when solving components of the task. Our results shed light on the difficulty of module specialization, what is required for modules to successfully specialize, and the necessity of modular architectures to achieve systematicity. Finally, we confirm that the theoretical results in our tractable setting generalize to more complex datasets and non-linear architectures

The relative age effect reversal among the National Hockey League elite

Like many sports in adolescence, junior hockey is organized by age groups. Typically, players born after December 31st are placed in the subsequent age cohort and as a result, will have an age advantage over those players born closer to the end of the year. While this relative age effect (RAE) has been well-established in junior hockey and other professional sports, the long-term impact of this phenomenon is not well understood. Using roster data on North American National Hockey League (NHL) players from the 2008-2009 season to the 2015-2016 season, we document a RAE reversal—players born in the last quarter of the year (October-December) score more and command higher salaries than those born in the first quarter of the year. This reversal is even more pronounced among the NHL “elite.” We find that among players in the 90th percentile of scoring, those born in the last quarter of the year score about 9 more points per season than those born in the first quarter. Likewise, elite players in the 90th percentile of salary who are born in the last quarter of the year earn 51% more pay than players born at the start of the year. Surprisingly, compared to players at the lower end of the performance distribution, the RAE reversal is about three to four times greater among elite players

Life cycle assessment of sponge nickel produced by gas atomisation for use in industrial hydrogenation catalysis applications

This paper presented results from a complete lifecycle assesment of various sponge nickel catalysts, produced in two different ways, namely either by gas atomisation or by the industrial standard techniques of cast and crush. The application considered was for the industrial hydrogentation of butyraldehyde to butanol. The paper describes the LCA methodology adopted which conformed to the ISO14040 standards, looking at various production scenarios and the impact on the emissions.The results indicated that the energy usage and emissions during the operation phase of the catalyst outweighed the primary production, manufacturing and recycling. It was shown that the increase in activity of gas atomised catalysts by doping with various metals, such as iron, molybdenum and tin, led to a significant reduction in emissions over the lifetime of the catalysts, which greatly outweighed the small increase in emissions at the primary extraction and manufacturing stages

Dynamics Generalisation in Reinforcement Learning via Adaptive Context-Aware Policies

While reinforcement learning has achieved remarkable successes in several domains, its real-world application is limited due to many methods failing to generalise to unfamiliar conditions. In this work, we consider the problem of generalising to new transition dynamics, corresponding to cases in which the environment's response to the agent's actions differs. For example, the gravitational force exerted on a robot depends on its mass and changes the robot's mobility. Consequently, in such cases, it is necessary to condition an agent's actions on extrinsic state information and pertinent contextual information reflecting how the environment responds. While the need for context-sensitive policies has been established, the manner in which context is incorporated architecturally has received less attention. Thus, in this work, we present an investigation into how context information should be incorporated into behaviour learning to improve generalisation. To this end, we introduce a neural network architecture, the Decision Adapter, which generates the weights of an adapter module and conditions the behaviour of an agent on the context information. We show that the Decision Adapter is a useful generalisation of a previously proposed architecture and empirically demonstrate that it results in superior generalisation performance compared to previous approaches in several environments. Beyond this, the Decision Adapter is more robust to irrelevant distractor variables than several alternative methods.Comment: Accepted to NeurIPS 202

Neural-humoral responses during head-up tilt in healthy young white and black women

Young black women have higher prevalence of hypertension during pregnancy compared to white women, which may be attributable to differences in blood pressure (BP) regulation. We hypothesized that young normotensive black women would demonstrate augmented muscle sympathetic nerve activity (MSNA) and renal-adrenal responses to orthostasis. Fifteen white and ten black women (30 ± 4 vs. 32 ± 6 years; means ± SD) had haemodynamics and MSNA measured during baseline (BL), 30 and 60° head-up tilt (HUT), and recovery. Blood was drawn for catecholamines, direct renin, vasopressin, and aldosterone. BL brachial systolic BP (SBP: 107 ± 6 vs. 101 ± 9 mmHg) and diastolic BP (DBP: 62 ± 4 vs. 56 ± 7 mmHg) were higher in white women (both p < 0.05). Δ DBP (60° HUT-BL) was greater in black women compared to white (p < 0.05). Cardiac output and total peripheral resistance were similar between groups. MSNA burst frequency was higher in whites (BL: 16 ± 10 vs. 14 ± 9 bursts/min, main effect p < 0.05) and increased in both groups during HUT (60°: 39 ± 8 vs. 34 ± 13 bursts/min, p < 0.05 from BL). Noradrenaline was higher in white women during 60° HUT (60° HUT: 364 ± 102 vs. 267 ± 89 pg/ml, p < 0.05). Direct renin was higher and vasopressin and Δ aldosterone tended to be higher in blacks (BL, direct renin: 12.1 ± 5.0 vs. 14.4 ± 3.7 pg/ml, p < 0.05; BL, vasopressin: 0.4 ± 0.0 vs. 1.6 ± 3.6 pg/ml, p = 0.065; Δ aldosterone: −0.9 ± 5.1 vs. 3.8 ± 7.5 ng/ml; p = 0.069). These results suggest that young normotensive white women may rely on sympathetic neural activity more so than black women who have a tendency to rely on the renal-adrenal system to regulate BP during an orthostatic stress

Evolution of Atmospheric O2 Through the Phanerozoic, Revisited

An oxygen-rich atmosphere is essential for complex animals. The early Earth had an anoxic atmosphere, and understanding the rise and maintenance of high O2 levels is critical for investigating what drove our own evolution and for assessing the likely habitability of exoplanets. A growing number of techniques aim to reproduce changes in O2 levels over the Phanerozoic Eon (the past 539 million years). We assess these methods and attempt to draw the reliable techniques together to form a consensus Phanerozoic O2 curve. We conclude that O2 probably made up around 5–10% of the atmosphere during the Cambrian and rose in pulses to ∼15–20% in the Devonian, reaching a further peak of greater than 25% in the Permo-Carboniferous before declining toward the present day. Evolutionary radiations in the Cambrian and Ordovician appear consistent with an oxygen driver, and the Devonian “Age of the Fishes” coincides with oxygen rising above 15% atm. ▪ An oxygen-rich atmosphere is essential for complex animals such as humans. ▪ We review the methods for reconstructing past variation in oxygen levels over the past 539 million years (the Phanerozoic Eon). ▪ We produce a consensus plot of the most likely evolution of atmospheric oxygen levels. ▪ Evolutionary radiations in the Cambrian, Ordovician, and Devonian periods may be linked to rises in oxygen concentration